doi: 10.3109/13813457609067051.
Incorporation of double-labelled valine into delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine by Penicillium chrysogenum
- PMID: 65951
- DOI: 10.3109/13813457609067051
Item in Clipboard
Incorporation of double-labelled valine into delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine by Penicillium chrysogenum
Arch Int Physiol Biochim.
1976 Oct.
Abstract
The incorporation of valine into the LLD-tripeptide, delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine, a precursor of penicillin, was studied by incubating mycelial mats of Penicillium chrysogenum Wis. 49-2105 with double labelled valines. L-valine was incorporated into the LLD-tripeptide without formation of an alpha, beta-didehydrovaline intermediate. Intact D-valine was not incorporated into the LLD-tripeptide.
Similar articles
-
Presence of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine in fermentations of Penicillium chrysogenum.Antimicrob Agents Chemother. 1975 Dec;8(6):638-42. doi: 10.1128/AAC.8.6.638. Antimicrob Agents Chemother. 1975. PMID: 813571 Free PMC article.
-
Glucose represses formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine and isopenicillin N synthase but not penicillin acyltransferase in Penicillium chrysogenum.J Bacteriol. 1986 Nov;168(2):947-52. doi: 10.1128/jb.168.2.947-952.1986. J Bacteriol. 1986. PMID: 3096965 Free PMC article.
-
Synthesis of delta-(alpha-aminoadipyl)cysteinylvaline and its role in penicillin biosynthesis.Biochem J. 1976 Sep 1;157(3):651-60. doi: 10.1042/bj1570651. Biochem J. 1976. PMID: 825110 Free PMC article.
-
δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine synthetase (ACVS): discovery and perspectives.J Ind Microbiol Biotechnol. 2017 May;44(4-5):517-524. doi: 10.1007/s10295-016-1850-7. Epub 2016 Oct 20. J Ind Microbiol Biotechnol. 2017. PMID: 27766439 Review.
-
Biochemistry of penicillin and cephalosporin fermentations.Lloydia. 1974 Jun;37(2):147-67. Lloydia. 1974. PMID: 4211838 Review. No abstract available.