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. 1976 Oct;84(4):767-70.
doi: 10.3109/13813457609067051.

Incorporation of double-labelled valine into delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine by Penicillium chrysogenum

P Adriaens, B Meesschaert, H Vanderhaeghe, H Eyssen

Incorporation of double-labelled valine into delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine by Penicillium chrysogenum

P Adriaens et al. Arch Int Physiol Biochim. 1976 Oct.

Abstract

The incorporation of valine into the LLD-tripeptide, delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine, a precursor of penicillin, was studied by incubating mycelial mats of Penicillium chrysogenum Wis. 49-2105 with double labelled valines. L-valine was incorporated into the LLD-tripeptide without formation of an alpha, beta-didehydrovaline intermediate. Intact D-valine was not incorporated into the LLD-tripeptide.

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