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. 1984;2(4):397-9.
doi: 10.1007/BF00171592.

Phase II trial of 4'-epi-doxorubicin in metastatic colorectal carcinoma

J A Wils

Phase II trial of 4'-epi-doxorubicin in metastatic colorectal carcinoma

J A Wils. Invest New Drugs. 1984.

Abstract

Twenty-three patients with metastatic colorectal carcinoma were treated with 4'-epi-doxorubicin (Epirubicin, 4'-epi-DX) 90 mg/m2 i.v. every 4 weeks. Out of 18 patients evaluable for response, 11 were previously untreated. One complete response of 21 + months was observed in a patient with rectosigmoid carcinoma. Furthermore there was one minor response in pretreated rectosigmoid series, and 6 patients had stabilization of disease. Median survival for all patients, including early deaths, was 4 months. For patients who were not pretreated and who received at least 2 cycles of therapy, median survival was 15 months. Further studies in patients with rectosigmoid carcinoma are warranted.

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