[Effect of diuretics on the humoral system of kidney prostaglandins in hypertension patients]

Abstract

Sixty-four patients with stage IIB essential hypertension were examined for the urinary excretion of prostaglandins E2 and F2 alpha, natriuresis and diuresis in the control period and then on the 3rd, and the 12th-14th day of the treatment with diuretics (furosemid, hypotiazid, oxodolin, brinaldix). All diuretics were found to alter the urinary PG excretion, with the degree of their effect depending on the type of the drug, the route and duration of its administration. Furosemid, to a greater degree than other diuretics, increased the urinary excretion of PGE2 thus bringing down the PGF2 alpha/PGE2 ratio, brinaldix increased PGF2 alpha excretion whereas hypotiazid, in cases of its prolonged employment, reduced the excretion of both PGs, the PGF2 alpha decrease being more prominent. PGE2 contributed to a decrease in BP and to the development of natriuresis. The physiological effect of PGF2 alpha depended on the status of the water-electrolyte balance in the body: in patients with IIB stage essential hypertension it facilitated the development of natriuresis and BP decrease. When following the administration of the diuretics the balance of sodium and water in the body lowered, PGF2 alpha caused the retention of sodium and water in the body and did not affect the BP.