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Case Reports
. 1984;13(4):329-33.
doi: 10.3109/03009748409111304.

Cyclosporin A treatment in a case of relapsing polychondritis

K L Svenson, R Holmdahl, L Klareskog, L Wibell, O Sjöberg, G B Klintmalm, H Boström
Case Reports

Cyclosporin A treatment in a case of relapsing polychondritis

K L Svenson et al. Scand J Rheumatol. 1984.

Abstract

A patient with relapsing polychondritis and high titres of anti-collagen II antibodies developed a progressive destruction of tracheal cartilage in spite of treatment with corticosteroids, Dapsone, Azathioprine and cyclophosphamide. Assumptions regarding the role of anti-collagen immunity, together with immunohistochemical studies on affected cartilage, suggested macrophage-T cell interactions to be important in the pathogenesis of the disease. Cyclosporin A treatment was instituted and has been continued for 2 years, concomitant with a steady improvement and remission of the disease.

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