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. 1983 Jan;39(1):233-8.
doi: 10.1128/iai.39.1.233-238.1983.

Antibody responses to Haemophilus influenzae type b and diphtheria toxin induced by conjugates of oligosaccharides of the type b capsule with the nontoxic protein CRM197

P Anderson

Antibody responses to Haemophilus influenzae type b and diphtheria toxin induced by conjugates of oligosaccharides of the type b capsule with the nontoxic protein CRM197

P Anderson. Infect Immun. 1983 Jan.

Abstract

Oligosaccharides were made from Haemophilus influenzae type b capsular polysaccharide and conjugated to CRM(197) by reductive amination. Conjugates were made with a range of lengths and multiplicities of saccharide chains. All elicited a strongly enhanced anti-H. influenzae type b capsular polysaccharide response when injected into weanling rabbits. One series of conjugates also elicited antibodies to diphtheria toxin.

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