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. 1983 May;80(9):2723-7.
doi: 10.1073/pnas.80.9.2723.

Normal mice express idiotypes related to autoantibody idiotypes of lupus mice

S K Datta, B D Stollar, R S Schwartz

Normal mice express idiotypes related to autoantibody idiotypes of lupus mice

S K Datta et al. Proc Natl Acad Sci U S A. 1983 May.

Abstract

Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.

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References

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