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Case Reports
. 1983 Jul;22(7):515-7.
doi: 10.1177/000992288302200711.

Citrobacter ventriculitis in a neonate responsive to trimethoprim-sulfamethoxazole

Case Reports

Citrobacter ventriculitis in a neonate responsive to trimethoprim-sulfamethoxazole

G R Greene et al. Clin Pediatr (Phila). 1983 Jul.

Abstract

There are increasing reports of citrobacter central nervous system infections in neonates. These organisms cause brain abcesses in a high percentage of patients. They may be resistant to commonly used antibiotics. We report a term male infant with underlying meningo-myelocoele and hydrocephalus in whom Citrobacter diversus meningitis and ventriculitis developed. Initial antibiotic therapy including intraventricular amikacin failed to sterilize the ventricles or alter a deteriorating clinical course. Adding intravenous trimethoprim-sulfamethoxazole to the therapeutic regimen resulted in reversal of a progressively worsening condition and eventual recovery. Trimethoprim-sulfamethoxazole should be considered as a potentially useful alternative antibiotic for susceptible central nervous system infections.

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