Delayed hypersensitivity in mast-cell-deficient mice

Abstract

The ability of mast cell-deficient Wf/Wf and W/Wv mice to produced delayed hypersensitivity responses was examined. The W/Wv mice did not have detectable mast cells and could not produce IgE-mediated passive cutaneous anaphylaxis. Mice of both genotypes produced large delayed hypersensitivity responses to the contact sensitizers oxazolone and picryl chloride. The responses were indistinguishable from responses of control mice when challenged with optimal or suboptimal doses of antigen. Delayed hypersensitivity could be transferred into Wf/Wf mice by an antigen-specific T cell line, and the proliferative responses in the lymph nodes of these mice after, painting with sensitizer, were normal.