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. 1983 Mar;6(3):175-8.
doi: 10.1016/0165-2478(83)90101-3.

Diminished interleukin-2 activity production in cancer patients bearing solid tumors and its relationship with natural killer cells

A Rey, B Klein, D Zagury, C Thierry, B Serrou

Diminished interleukin-2 activity production in cancer patients bearing solid tumors and its relationship with natural killer cells

A Rey et al. Immunol Lett. 1983 Mar.

Abstract

Interleukin-2 (IL-2) activity production by stimulated peripheral blood lymphocytes (PBL) from solid tumor bearing cancer patients was lower than in normal subjects. Natural-killer (NK) cell activity in the PBL of cancer patients was very significantly correlated to IL-2 activity production (P less than 0.001). These results might suggest a central role for IL-2 in the immune dysfunctions in cancer patients, and the possible use of IL-2 as an immunological response modifier in these patients.

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