Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1983 Apr;15(2):95-8.

The effect of tamoxifen in intermediate alpha 1-antitrypsin deficiency associated with the phenotype PiSZ

S Eriksson
  • PMID: 6603815
Case Reports

The effect of tamoxifen in intermediate alpha 1-antitrypsin deficiency associated with the phenotype PiSZ

S Eriksson. Ann Clin Res. 1983 Apr.

Abstract

Three patients, one with lung disease and two with liver disease, with intermediate alpha 1-antitrypsin (AAT) deficiency phenotype PiSZ, (plasma AAT concentration approximately 1/3 of normal) were treated with the anti-oestrogen drug, tamoxifen, for 2-24 months. Patients responded with 50-70% increases in plasma AAT concentrations. Progress of emphysema appeared to be retarded in one case but no improvement in liver function was recorded in the other two patients.

PubMed Disclaimer

Publication types