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. 1983 Nov 25;11(22):8031-6.
doi: 10.1093/nar/11.22.8031.

Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine

B C Froehler, M D Matteucci
Free PMC article

Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine

B C Froehler et al. Nucleic Acids Res. .
Free PMC article

Abstract

Sterically hindered N6-dialkylformamidine protected deoxyadenosine is more stable to acidic depurination than N6-benzoyldeoxyadenosine and is potentially a valuable protecting group in the synthesis of deoxyoligonucleotides.

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References

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    1. Nucleic Acids Res. 1982 May 25;10(10):3249-60 - PubMed