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. 1983 Nov;22(4 Suppl 2):18-9.
doi: 10.1093/rheumatology/xxii.suppl_2.18.

The risk of developing ankylosing spondylitis in HLA-B27 positive individuals: a family and population study

S van der Linden, H Valkenburg, A Cats

The risk of developing ankylosing spondylitis in HLA-B27 positive individuals: a family and population study

S van der Linden et al. Br J Rheumatol. 1983 Nov.

Abstract

In a family study, sacroiliitis was found in 15 (25%) out of 61 HLA-B27 positive first-degree relatives (FDR) of 20 randomly chosen HLA-B27 positive ankylosing spondylitis (AS) patients and never in 41 HLA-B27 negative FDR. Eight (53%) of the 15 FDR with sacroiliitis fulfilled the New York criteria for AS. In the population study the prevalence of HLA-B27 positive AS was found to be 0.1%. AS will develop in 1.3% of all HLA-B27 positive individuals belonging to the general population.

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