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Case Reports
. 1984 Jan;85(1):133-5.
doi: 10.1378/chest.85.1.133.

Amiodarone-induced hypersensitivity pneumonitis. Evidence of an immunological cell-mediated mechanism

G M Akoun, S Gauthier-Rahman, B J Milleron, J Y Perrot, C M Mayaud
Case Reports

Amiodarone-induced hypersensitivity pneumonitis. Evidence of an immunological cell-mediated mechanism

G M Akoun et al. Chest. 1984 Jan.

Abstract

Interstitial pneumonitis developed in a patient who had received a cumulative dose of 985 g of amiodarone in nine years. No other cause for pneumonitis was found. The following findings favor an immunologic mechanism of hypersensitivity due to amiodarone: positive skin and basophil degranulation tests with amiodarone; lymphocytosis and inverted ratio of helper/suppressor T lymphocytes in bronchoalveolar lavage fluid; secretion of leukocyte inhibitory factor, as shown by the inhibition of migration of peripheral blood leukocytes; and positive lymphoblastic transformation in the presence of amiodarone.

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