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. 1983 Dec 15;39(12):1389-90.
doi: 10.1007/BF01990119.

Effects of macrolide antibiotics on barbiturate sleeping time in mice

J Descotes, J C Evreux

Effects of macrolide antibiotics on barbiturate sleeping time in mice

J Descotes et al. Experientia. .

Abstract

Triacetyloleandomycin and josamycin, when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg per kg over 3 days, were found to increase barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate, erythromycin propionate, midecamycin and spiramycin were devoid of any such activity under the same conditions.

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