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Comparative Study
. 1983;275(5):305-9.
doi: 10.1007/BF00417202.

Cysteine proteinase inhibitors in psoriatic epidermis

V K Hopsu-Havu, I A Joronen, M Järvinen, A Rinne
Comparative Study

Cysteine proteinase inhibitors in psoriatic epidermis

V K Hopsu-Havu et al. Arch Dermatol Res. 1983.

Abstract

Human psoriatic epidermis and scales were demonstrated to contain two antigenically separate cysteine proteinase inhibitors, one acidic with an isoelectric point of 4.7-5.0 (ACPI) and one neutral with an isoelectric point of 6.0-6.5 (NCPI), while normal epidermis contains only ACPI. The total papain (cysteine proteinase) inhibiting activity of the psoriatic epidermis as calculated per mg protein was higher than that in normal epidermis. Both ACPI and NCPI were localized immunocytochemically, mainly in the highest spinous cell layers with less activity in the parakeratotic cells and lower layers of spinous cells. Basal cells were essentially negative.

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References

    1. Biochim Biophys Acta. 1977 Jul 8;483(1):160-71 - PubMed
    1. Biochim Biophys Acta. 1982 Nov 9;708(2):210-7 - PubMed
    1. Acta Histochem. 1978;63(2):183-92 - PubMed
    1. Acta Chem Scand B. 1976;30(10):933-40 - PubMed
    1. Immunochemistry. 1965 Sep;2(3):235-54 - PubMed

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