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Clinical Trial
. 1984 Feb;66(2):165-71.
doi: 10.1042/cs0660165.

Prostaglandins cause an increase in serum acute-phase proteins in man, which is diminished in systemic sclerosis

J T Whicher, A M Bell, M F Martin, L A Marshall, P A Dieppe
Clinical Trial

Prostaglandins cause an increase in serum acute-phase proteins in man, which is diminished in systemic sclerosis

J T Whicher et al. Clin Sci (Lond). 1984 Feb.

Abstract

The prostaglandin E1 increases the plasma concentration of acute-phase proteins in man and decreases the concentration of certain carrier proteins. This response is greatly diminished in patients with systemic sclerosis, a chronic inflammatory disease leading to fibrosis. These findings pose new questions about the mediation of the acute-phase response and its role in controlling the inflammatory process.

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