Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1984 Jan 1;159(1):126-36.
doi: 10.1084/jem.159.1.126.

Identification of a specific interleukin 1 inhibitor in the urine of febrile patients

Z Liao, R S Grimshaw, D L Rosenstreich

Identification of a specific interleukin 1 inhibitor in the urine of febrile patients

Z Liao et al. J Exp Med. .

Abstract

The urine of febrile patients has been found to contain high concentrations of an inhibitor of interleukin 1 (IL-1)-induced thymocyte proliferation. The inhibitor is specific for IL-1 and does not block the effects of interleukin 2 (IL-2) or phytohemagglutin (PHA) on thymocytes, and it is not nonspecifically toxic for these cells. IL-1 inhibitor can be found in the urine of normal individuals and afebrile patients, but is present in increased concentrations in the urine of patients with fever of diverse etiologies. Preliminary physicochemical characterization indicates that the inhibitor is a 20-40-kdalton protein.

PubMed Disclaimer

References

    1. J Immunol. 1983 Apr;130(4):1764-9 - PubMed
    1. J Immunol. 1980 Aug;125(2):793-8 - PubMed
    1. Nature. 1980 Jun 12;285(5765):498-500 - PubMed
    1. Aust N Z J Med. 1980 Aug;10(4):449-53 - PubMed
    1. J Immunol. 1980 Dec;125(6):2555-8 - PubMed

Publication types