In-vitro and in-vivo antibacterial activity of imipenem against clinical isolates of bacteria
- PMID: 6607914
- DOI: 10.1093/jac/12.suppl_d.53
In-vitro and in-vivo antibacterial activity of imipenem against clinical isolates of bacteria
Abstract
Imipenem, a derivative of thienamycin, a carbapenem antibiotic, has a broad spectrum of activity against aerobic (Gram-positive and Gram-negative) and anaerobic bacteria. It is quite stable to all tested beta-lactamases produced by various species of bacteria isolated from clinical specimens, whether plasmid or chromosomally mediated. One exception is its hydrolysis by the beta-lactamase produced by Pseudomonas maltophilia which is thus usually resistant to imipenem. Imipenem was found to be hydrolysed by renal dehydropeptidase-I residing on the luminal surface of the renal tubular epithelium. A dehydropeptidase-I inhibitor, cilastatin (MK-0791) was developed with specific inhibitory activity toward the renal dehydropeptidase-I and showed detectable effects in humans.
Similar articles
-
In vitro activity of LJC10,627, a new carbapenem antibiotic with high stability to dehydropeptidase I.Antimicrob Agents Chemother. 1990 Jun;34(6):994-1000. doi: 10.1128/AAC.34.6.994. Antimicrob Agents Chemother. 1990. PMID: 2203313 Free PMC article.
-
Biochemical comparison of imipenem, meropenem and biapenem: permeability, binding to penicillin-binding proteins, and stability to hydrolysis by beta-lactamases.J Antimicrob Chemother. 1995 Jan;35(1):75-84. doi: 10.1093/jac/35.1.75. J Antimicrob Chemother. 1995. PMID: 7768785
-
Review of the in vitro spectrum of activity of imipenem.Am J Med. 1985 Jun 7;78(6A):22-32. doi: 10.1016/0002-9343(85)90098-1. Am J Med. 1985. PMID: 3890537 Review.
-
Mechanisms by which imipenem may overcome resistance in gram-negative bacilli.J Antimicrob Chemother. 1986 Dec;18 Suppl E:9-13. doi: 10.1093/jac/18.supplement_e.9. J Antimicrob Chemother. 1986. PMID: 3493237
-
Thienamycin: development of imipenen-cilastatin.J Antimicrob Chemother. 1983 Dec;12 Suppl D:1-35. doi: 10.1093/jac/12.suppl_d.1. J Antimicrob Chemother. 1983. PMID: 6365872 Review.
Cited by
-
In vitro antibacterial activity of LJC 11,036, an active metabolite of L-084, a new oral carbapenem antibiotic with potent antipneumococcal activity.Antimicrob Agents Chemother. 1999 Aug;43(8):2010-6. doi: 10.1128/AAC.43.8.2010. Antimicrob Agents Chemother. 1999. PMID: 10428928 Free PMC article.
-
Imipenem/cilastatin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy.Drugs. 1987 Mar;33(3):183-241. doi: 10.2165/00003495-198733030-00001. Drugs. 1987. PMID: 3552595 Review.
-
Failure of newer beta-lactam antibiotics for murine Yersinia enterocolitica infection.Antimicrob Agents Chemother. 1987 Apr;31(4):523-6. doi: 10.1128/AAC.31.4.523. Antimicrob Agents Chemother. 1987. PMID: 3475033 Free PMC article.
-
Transferable imipenem resistance in Pseudomonas aeruginosa.Antimicrob Agents Chemother. 1991 Jan;35(1):147-51. doi: 10.1128/AAC.35.1.147. Antimicrob Agents Chemother. 1991. PMID: 1901695 Free PMC article.
-
In vitro activity of biapenem against clinical isolates of gram-positive and gram-negative bacteria.Antimicrob Agents Chemother. 1993 Sep;37(9):2009-16. doi: 10.1128/AAC.37.9.2009. Antimicrob Agents Chemother. 1993. PMID: 8239623 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources