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Comparative Study
. 1984 Mar 27;138(1):1-8.
doi: 10.1016/0009-8981(84)90348-6.

Rapid diagnosis of congenital adrenal hyperplasia by high performance liquid chromatography

Y Weisman, A Bar, A Root, Z Spirer, A Golander
Comparative Study

Rapid diagnosis of congenital adrenal hyperplasia by high performance liquid chromatography

Y Weisman et al. Clin Chim Acta. .

Abstract

This manuscript describes methods for the quantitation of serum concentrations of 17-hydroxyprogesterone and 11-deoxycortisol (Compound S) employing reverse-phase high-performance liquid chromatography (HPLC) and ultraviolet (UV) absorbance which are applicable to the diagnosis of congenital adrenal hyperplasia due to deficiencies of 21- and 11-hydroxylase activities, respectively. These methods are simple, specific, precise and rapid. Data obtained by the HPLC-UV methods are highly correlated (p less than 0.001) with radioimmunoassay measurements.

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