doi: 10.1016/0090-1229(84)90245-9.
One subset of patients with retinitis pigmentosa has immunologic defects
- PMID: 6609039
- DOI: 10.1016/0090-1229(84)90245-9
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One subset of patients with retinitis pigmentosa has immunologic defects
Clin Immunol Immunopathol.
1984 May.
Abstract
Immunological evaluation of 20 patients with retinitis pigmentosa (RP) revealed significantly diminished circulating T-lymphocyte numbers and function and a high frequency of serum antibodies to human IgG in comparison with a healthy matched control population. However, these differences were due to severely abnormal results found in one subpopulation within the total patient group; this dichotomy was unrelated to the mode of inheritance or clinical severity of RP in individual patients. Thus, RP appears to be a syndrome rather than a disease and includes a form characterized by defective immunity. Whether this is involved in the pathogenesis of the retinal degenerative process is conjectural.
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