Comparative Study
doi: 10.1080/09553008414550651.
Chromosome aberrations in human lymphocytes induced by fission neutrons
- PMID: 6609897
- DOI: 10.1080/09553008414550651
Item in Clipboard
Comparative Study
Chromosome aberrations in human lymphocytes induced by fission neutrons
Int J Radiat Biol Relat Stud Phys Chem Med.
1984 May.
Abstract
The dose-response relationships of dicentrics and excess acentrics were analysed after exposure of human lymphocytes to a mixed fission neutron-gamma-ray beam. From the analysis of exclusively first division cells a linear-quadratic relation was obtained for dicentrics with the ratio of linear and quadratic components, zeta, equal to 2.76 Gy. Over the range of doses studied (0.04-1.97 Gy) intratrack events therefore predominated. This also applied to acentrics which were linearly related to dose. At the lowest level of observed effect and dose, r.b.e. values with respect to 60Co gamma-rays of up to about 11 were derived for dicentrics and acentrics. With increasing neutron dose the r.b.e. decreased.
Similar articles
-
Dose-response relationship of dicentric chromosomes in human lymphocytes obtained for the fission neutron therapy facility MEDAPP at the research reactor FRM II.Radiat Environ Biophys. 2009 Feb;48(1):67-75. doi: 10.1007/s00411-008-0202-z. Epub 2008 Nov 1. Radiat Environ Biophys. 2009. PMID: 18979115
-
Induction of chromosome aberrations in G0 human lymphocytes by low doses of ionizing radiations of different quality.Radiat Res. 1985 Jul;103(1):122-34. Radiat Res. 1985. PMID: 4070557
-
Dose-response relationships of micronuclei in human lymphocytes induced by fission neutrons and by low LET radiations.Mutat Res. 1994 Apr 15;306(2):135-41. doi: 10.1016/0027-5107(94)90024-8. Mutat Res. 1994. PMID: 7512212
-
Chromosome aberration frequencies in human lymphocytes irradiated in a phantom by a mixed beam of fission neutrons and gamma-rays.Int J Radiat Biol. 1998 Mar;73(3):263-7. doi: 10.1080/095530098142356. Int J Radiat Biol. 1998. PMID: 9525254
-
Radiation induced chromosome aberrations and the Poisson distribution.Radiat Environ Biophys. 1979 Apr 30;16(2):89-100. doi: 10.1007/BF01323216. Radiat Environ Biophys. 1979. PMID: 472118
Cited by
-
Dose-response relationship of dicentric chromosomes in human lymphocytes obtained for the fission neutron therapy facility MEDAPP at the research reactor FRM II.Radiat Environ Biophys. 2009 Feb;48(1):67-75. doi: 10.1007/s00411-008-0202-z. Epub 2008 Nov 1. Radiat Environ Biophys. 2009. PMID: 18979115
-
Comparison between two FISH techniques in the in vitro study of cytogenetic markers for low-dose X-ray exposure in human primary fibroblasts.Front Genet. 2013 Jul 29;4:141. doi: 10.3389/fgene.2013.00141. eCollection 2013. Front Genet. 2013. PMID: 23908663 Free PMC article.
-
Neutron relative biological effectiveness in Hiroshima and Nagasaki atomic bomb survivors: a critical review.J Radiat Res. 2016 Nov;57(6):583-595. doi: 10.1093/jrr/rrw079. Epub 2016 Sep 10. J Radiat Res. 2016. PMID: 27614201 Free PMC article. Review.
-
Relative biological effects of neutron mixed-beam irradiation for boron neutron capture therapy on cell survival and DNA double-strand breaks in cultured mammalian cells.J Radiat Res. 2013 Jan;54(1):70-5. doi: 10.1093/jrr/rrs079. Epub 2012 Sep 10. J Radiat Res. 2013. PMID: 22966174 Free PMC article.
-
Cell survival and radiation induced chromosome aberrations. I. Derivation of formulae for the determination of transmission and survival parameters of aberrations.Radiat Environ Biophys. 1986;25(4):243-51. doi: 10.1007/BF01214637. Radiat Environ Biophys. 1986. PMID: 3823371