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Comparative Study
. 1983 Jul 1;31(1):163-76.
doi: 10.1016/0049-3848(83)90017-8.

The megakaryocyte in thrombocytopenia: a microscopic study which supports the theory that platelets are produced in the pulmonary circulation

D N Slater, E A Trowbridge, J F Martin
Comparative Study

The megakaryocyte in thrombocytopenia: a microscopic study which supports the theory that platelets are produced in the pulmonary circulation

D N Slater et al. Thromb Res. .

Abstract

Thrombocytopenia can increase platelet production and thereby facilitate investigations into the mechanism. Megakaryocytes in the bone marrow, lung, spleen and liver have been studied by light and transmission electron microscopy after 6 days of experimentally induced thrombocytopenia in the rabbit. The findings support the theory that platelets are produced in the pulmonary circulation by the physical fragmentation of megakaryocyte cytoplasm.

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