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. 1983 Aug;16(2):185-7.
doi: 10.1111/j.1365-2125.1983.tb04983.x.

Colonic release of 5-amino salicylic acid from an oral preparation in active ulcerative colitis

M J Dew, R E Ryder, N Evans, B K Evans, J Rhodes

Colonic release of 5-amino salicylic acid from an oral preparation in active ulcerative colitis

M J Dew et al. Br J Clin Pharmacol. 1983 Aug.

Abstract

5-amino salicylic acid coated with acrylic based resin was given orally to eight patients with active ulcerative colitis. Abdominal X-rays confirmed that the preparation released its contents in the terminal ileum and proximal colon. Differences between individuals were marked; the plasma 'concentration-time profile' reflected variations in the time taken for tablets to reach the terminal ileum.

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