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. 1983;14(4):461-3.
doi: 10.1016/0306-3623(83)90031-9.

Effect of biogenic amines reuptake inhibition on ethanol induced hypothermia

K F Soliman, N N Gabriel

Effect of biogenic amines reuptake inhibition on ethanol induced hypothermia

K F Soliman et al. Gen Pharmacol. 1983.

Abstract

The mechanism of ethanol induced hypothermia (EIH) was examined by the use of chemically related compounds which inhibit 5-hydroxytryptamine (5-HT) or norepinephrine (NE) reuptake. Desipramine, a tricyclic antidepressant drug (TCA) and NE reuptake inhibitor partially antagonizes EIH. However, Nisoxetine (NE reuptake inhibitor but not TCA) did not abolish EIH. Chlorimipramine, a TCA compound and 5-HT reuptake inhibitor abolishes EIH. Meanwhile, fluoxetine (5-HT reuptake inhibitor, but not TCA) potentiated ethanol induced hypothermia. It was concluded that the antagonism of EIH is probably related to the antidepressant effect of TCA compounds.

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