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. 1983 Aug;20(4):255-8.
doi: 10.1136/jmg.20.4.255.

Genetic linkage between Becker muscular dystrophy and a polymorphic DNA sequence on the short arm of the X chromosome

H M Kingston, N S Thomas, P L Pearson, M Sarfarazi, P S Harper

Genetic linkage between Becker muscular dystrophy and a polymorphic DNA sequence on the short arm of the X chromosome

H M Kingston et al. J Med Genet. 1983 Aug.

Abstract

A study of DNA restriction fragment polymorphisms and Becker muscular dystrophy has shown eight families informative for the cloned sequence L1.28, which is located on the short arm of the X chromosome between Xp110 and Xp113. Analysis of these families reveals linkage between the two loci, with the maximum likelihood estimate of the genetic distance being 16 centiMorgans (95% confidence limits between 7 and 32 centiMorgans). Since a study of DNA polymorphisms in Duchenne muscular dystrophy has shown a comparable linkage distance with L1.28, our results suggest that the locus for Becker muscular dystrophy, like that for Duchenne dystrophy, is on the short arm of the X chromosome, and further that these two loci may be closely linked or possibly allelic.

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References

    1. Ann Hum Genet. 1969 Jan;32(3):261-9 - PubMed
    1. Am J Hum Genet. 1974 Sep;26(5):588-97 - PubMed
    1. J Med Genet. 1974 Dec;11(4):317-20 - PubMed
    1. J Med Genet. 1974 Dec;11(4):321-7 - PubMed
    1. J Mol Biol. 1975 Nov 5;98(3):503-17 - PubMed

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