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. 1983 Jul;15(7):683-96.
doi: 10.1016/s0031-6989(83)80040-x.

Anti-inflammatory activity of S-adenosyl-L-methionine: interference with the eicosanoid system

M Gualano, G Stramentinoli, F Berti

Anti-inflammatory activity of S-adenosyl-L-methionine: interference with the eicosanoid system

M Gualano et al. Pharmacol Res Commun. 1983 Jul.

Abstract

S-adenosyl-L-methionine (SAMe) displays anti-inflammatory as well as antalgic activity without damaging the gastrointestinal mucosa in experimental animals. In fact, carrageenin-induced edema in rats and writhings provoked in mice by phenylquinone and acetic acid are controlled by SAMe in a dose dependent manner. Since PG-like substance concentration in the inflammatory exudate decreased in SAMe-treated animals the mode of action of this compound is also discussed, in view of SAMe ability to interfere with the eicosanoid system.

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