A mutagen produced by Fusarium moniliforme

Abstract

A mutagenic compound produced by Fusarium moniliforme on maize was isolated by CHCl3--iso-PrOH extraction, solvent partitioning and liquid chromatography on silica gel and Sephadex LH-20. HPLC studies showed that different mutagenic and non-mutagenic forms can be derived from the mutagen (P3) and that prolonged exposure to longwave u.v. light and to high temperatures causes a total loss of its u.v. absorption and mutagenic characteristics. Spectral data presented for P3 include u.v., i.r., mass spectra as well as 1H NMR and 13C NMR. Mass spectral data indicated a molecular formula of C23H29NO7.