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. 1983 Sep 15;214(3):777-84.
doi: 10.1042/bj2140777.

Specific interaction between cartilage proteoglycans and hyaluronic acid at the chondrocyte cell surface

Y Sommarin, D Heinegård

Specific interaction between cartilage proteoglycans and hyaluronic acid at the chondrocyte cell surface

Y Sommarin et al. Biochem J. .

Abstract

Binding of exogenous [35S]sulphate-labelled cartilage proteoglycans to cells was studied with suspension cultures of calf articular-cartilage chondrocytes. Proteoglycans interact with hyaluronic acid at the cell surface via their hyaluronic acid-binding region. The binding is time-dependent and saturable, but does not appear to be freely reversible. The bound 35S-labelled proteoglycans are located at the cell surface, and only small proportions of the proteoglycans are internalized.

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