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. 1983 Sep 15;214(3):991-3.
doi: 10.1042/bj2140991.

An intermediary role for the tremorgenic mycotoxin TR-2 in the biosynthesis of verruculogen

J Willingale, K P Perera, P G Mantle

An intermediary role for the tremorgenic mycotoxin TR-2 in the biosynthesis of verruculogen

J Willingale et al. Biochem J. .

Abstract

14C-Labelled compound TR-2, a tremorgenic mycotoxin, was administered to Penicillium raistrickii in submerged fermentation. Half of the added radiolabel was taken up by the fungus during the 60 h incubation period and the secondary metabolites subsequently isolated, principally verruculogen but also fumitremorgin B, were found to be radiolabelled. The efficiency of biosynthetic incorporation of TR-2 into verruculogen within the mycelium was at least 35%, demonstrating for the first time an intermediary role for TR-2. Fumitremorgin B was also TR-2-derived but may not be an important intermediate in verruculogen biosynthesis.

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