Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983;88(3):184-9.
doi: 10.1007/BF00285618.

Meiosis in the foetal mouse ovary. II. Oocyte development and age-related aneuploidy. Does a production line exist?

R M Speed, A C Chandley

Meiosis in the foetal mouse ovary. II. Oocyte development and age-related aneuploidy. Does a production line exist?

R M Speed et al. Chromosoma. 1983.

Abstract

A systematic search for chromosome pairing defects in foetal mouse oocytes has been carried out in two different strains (Swiss and CBA/Ca) over days 15-19 of gestation and on day 1 post-partum. The aim was to seek direct cytological evidence for a "production line" of oocyte development, or the occurrence of pairing anomalies at meiotic prophase that might lead, in the adult female, to nondisjunction at anaphase I. No evidence for either was found. The data argue against the "production line" hypothesis as the basis for maternal age-related increases in aneuploidy in the mouse. Attempts to analyse chiasmata in oocytes at diplotene were unsuccessful.

PubMed Disclaimer

References

    1. Hum Genet. 1981;57(3):247-52 - PubMed
    1. Exp Cell Res. 1961 Sep;24:495-507 - PubMed
    1. Cytogenet Cell Genet. 1983;35(1):57-63 - PubMed
    1. Cytogenet Cell Genet. 1983;35(1):34-40 - PubMed
    1. Cytogenet Cell Genet. 1976;16(6):505-29 - PubMed