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. 1983 Oct;18(4):1006-7.
doi: 10.1128/jcm.18.4.1006-1007.1983.

Concomitance of cytotoxigenic and non-cytotoxigenic Clostridium difficile in stool specimens

S P Borriello, P Honour

Concomitance of cytotoxigenic and non-cytotoxigenic Clostridium difficile in stool specimens

S P Borriello et al. J Clin Microbiol. 1983 Oct.

Abstract

Six patients with antibiotic-associated diarrhea and one patient with diarrhea unrelated to antibiotic use yielded both cytotoxigenic and non-cytotoxigenic isolates of Clostridium difficile from the same stool specimens. In addition, these isolates were shown to be pathogenic and nonpathogenic, respectively, in the hamster model of antibiotic-associated colitis. These data imply that more than one toxin type of C. difficile may be harbored simultaneously. If toxin testing is used to identify C. difficile, more than one colony must be tested.

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