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. 1983 Aug-Sep;60(3):353-62.
doi: 10.1016/0022-510x(83)90145-4.

Effects of 4-aminopyridine in patients with multiple sclerosis

R E Jones, J R Heron, D H Foster, R S Snelgar, R J Mason

Effects of 4-aminopyridine in patients with multiple sclerosis

R E Jones et al. J Neurol Sci. 1983 Aug-Sep.

Abstract

4-Aminopyridine (4-AP) was administered to two groups of patients with multiple sclerosis (MS). The first group consisted of 5 patients with labile visual symptoms, 2 of whom had arcuate scotomata. 4-AP improved visual performance of most patients in this group and reduced the size of scotomata. The second group consisted of 5 patients with the spinal form of MS who were in a stable state; in this group 4-AP had little effect clinically or on tests of visual function.

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