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. 1983 Nov;35(5):410-6.
doi: 10.1016/0022-4804(83)90030-6.

Healing of hyaluronic acid-enriched wounds: histological observations

G Abatangelo, M Martelli, P Vecchia

Healing of hyaluronic acid-enriched wounds: histological observations

G Abatangelo et al. J Surg Res. 1983 Nov.

Abstract

The influence of an exogenous supply of Na hyaluronate (HA) on the healing of superficial skin wounds in healthy and alloxan-induced diabetic rats was histologically assessed. Rats were treated by topical application on the wound site of a 2% Na hyaluronate solution. A facilitating effect of the HA-enrichment on wound repair processes (particularly epithelial migration and differentiation) was markedly evident in wounded diabetic rats. This result is discussed in terms of a possible favorable influence of an HA-enriched wound environment on cell migratory processes occurring during wound healing.

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