[Enhanced capture by tumor cells of liposomes prepared from autologous phospholipids]

Abstract

The trapping of liposomes from native phospholipids by tumor cells was found to be 2-6 times that of egg lecithin vesicles. These differences in the level of incorporation of the two types of liposomes in the course of incubation with ascitic lymphocytic leukemia cells NKLy/LL seem to be due to the different mechanisms of their utilization. Egg lecithin liposomes are trapped via endocytosis which is not highly pronounced in these cells, whereas vesicles from target-cell phospholipids are incorporated by fusion mechanism.