Prolonged delirium without anticholinergic signs following amitriptyline overdose
- PMID: 6640457
- PMCID: PMC1875538
Prolonged delirium without anticholinergic signs following amitriptyline overdose
Abstract
In a case of acute intoxication with a tricyclic antidepressant (amitriptyline) delirium was prolonged without there being prominent peripheral anticholinergic or electrocardiographic signs. Administration of physostigmine, repeated when necessary, reversed the delirium.
Similar articles
-
Continuous infusion of physostigmine in anticholinergic delirium: case report.J Clin Psychiatry. 1983 Dec;44(12):463-4. J Clin Psychiatry. 1983. PMID: 6654839
-
Reversal of delirium induced by tricyclic antidepressant drugs with physostigmine.Am J Psychiatry. 1974 Nov;131(11):1275-7. doi: 10.1176/ajp.131.11.1275. Am J Psychiatry. 1974. PMID: 4424019 No abstract available.
-
Physostigmine treatment of delirium induced by anticholinergics.Am Fam Physician. 1976 May;13(5):99-103. Am Fam Physician. 1976. PMID: 1274812
-
Safety and effectiveness of physostigmine: a 10-year retrospective review<sup/>Clin Toxicol (Phila). 2018 Feb;56(2):101-107. doi: 10.1080/15563650.2017.1342828. Epub 2017 Jul 13. Clin Toxicol (Phila). 2018. PMID: 28703024 Review.
-
Pharmacological management of anticholinergic delirium - theory, evidence and practice.Br J Clin Pharmacol. 2016 Mar;81(3):516-24. doi: 10.1111/bcp.12839. Epub 2015 Dec 29. Br J Clin Pharmacol. 2016. PMID: 26589572 Free PMC article. Review.
Cited by
-
Physiologically based pharmacokinetic-quantitative systems toxicology and safety (PBPK-QSTS) modeling approach applied to predict the variability of amitriptyline pharmacokinetics and cardiac safety in populations and in individuals.J Pharmacokinet Pharmacodyn. 2018 Oct;45(5):663-677. doi: 10.1007/s10928-018-9597-6. Epub 2018 Jun 25. J Pharmacokinet Pharmacodyn. 2018. PMID: 29943290 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical