doi: 10.1007/BF01990384.
The effect of jaundiced sera and bile salts on cultured beating rat heart cells
- PMID: 6641911
- DOI: 10.1007/BF01990384
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The effect of jaundiced sera and bile salts on cultured beating rat heart cells
Experientia.
.
Abstract
Jaundiced serum from common bile duct ligated rats, added to cultured heart cells, decreased the beating rate, caused an early cessation of beating and production of higher levels of lactate in the media. Deoxycholate and cholate are the main bile acids in jaundiced serum; deoxycholate caused similar effects, which suggests that it is the toxic substance responsible for heart function alterations seen in patients with severe jaundice.
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