Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Nov 14;163(2):311-4.
doi: 10.1016/0014-5793(83)80842-4.

Diazepam inhibits cell respiration and induces fragmentation of mitochondrial reticulum

I A Vorobjev, D B Zorov
Free article

Diazepam inhibits cell respiration and induces fragmentation of mitochondrial reticulum

I A Vorobjev et al. FEBS Lett. .
Free article

Abstract

Diazepam (70-150 micrograms/ml) significantly inhibits oxygen consumption by pig kidney embryo cells and causes the cellular ATP level to fall. The maximum inhibitory effect develops after 1.5-2.5 h of diazepam treatment. In isolated mitochondria diazepam inhibits respiration in state 2 and 3u with glutamate and in state 3u with succinate. Ethylrhodamine staining and electron microscopic study reveal fragmentation of mitochondria in living cells.

PubMed Disclaimer

LinkOut - more resources