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. 1983 Oct;72(10):1203-5.
doi: 10.1002/jps.2600721024.

Determination of busulfan in plasma by GC-MS with selected-ion monitoring

H Ehrsson, M Hassan

Determination of busulfan in plasma by GC-MS with selected-ion monitoring

H Ehrsson et al. J Pharm Sci. 1983 Oct.

Abstract

A GC-MS technique with selected-ion monitoring is described for the determination of busulfan in plasma. Busulfan is extracted from plasma with methylene chloride and converted to 1,4-diiodobutane. Analysis by GC-MS with selected-ion monitoring (m/z 183) gave a relative standard deviation of +/- 4.3% (n = 5) at the 10-ng/ml level.

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