Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Dec;306(5943):551-7.
doi: 10.1038/306551a0.

Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development

J J Mekalanos, D J Swartz, G D Pearson, N Harford, F Groyne, M de Wilde

Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development

J J Mekalanos et al. Nature. 1983 Dec.

Abstract

Nucleotide sequence and deletion analysis have been used to identify the regulatory and coding sequences comprising the cholera toxin operon (ctx). Incorporation of defined in vitro-generated ctx deletion mutations into Vibrio cholerae by in vivo genetic recombination produced strains which have practical value in cholera vaccine development.

PubMed Disclaimer

Publication types

Associated data

LinkOut - more resources