Pancreatic somatostatinoma. Clinical features and physiological implications
- PMID: 66472
- DOI: 10.1016/s0140-6736(77)92113-4
Pancreatic somatostatinoma. Clinical features and physiological implications
Abstract
The first case of a tumour producing somatostatin-like immunoreactivity and bioactivity is presented. The pancreatic tumour was composed of cells indistinguishable from islet D cells. Radioimmunoassay of blood-samples obtained by tumour-vein catheterisation revealed very high levels of somatostatin immunoreactivity. On gel chromatography tumour extracts were found to contain at least 4 different immunoreactive components, one of which eluted in the position of synthetic somatostatin. Extracts from the tumour were potent in inhibiting insulin and glucagon secretion from isolated perfused porcine pancreas. Clinical abnormalities included hypochlorhydria, steatorrhoea, and diabetic glucose tolerance. Conceivably some of these abnormalities may be related to somatostatin hypersecretion from the pancreatic tumour.
Similar articles
-
Immunoreactive somatostatin in pancreatic islet-cell carcinoma accompanied by ectopic A.C.T.H. syndrome.Lancet. 1977 Jun 25;1(8026):1365-6. doi: 10.1016/s0140-6736(77)92578-8. Lancet. 1977. PMID: 69082 No abstract available.
-
Suppression of pancreatic endocrine tumour secretion by long-acting somatostatin analogue.Lancet. 1979 Oct 13;2(8146):764-7. doi: 10.1016/s0140-6736(79)92115-9. Lancet. 1979. PMID: 90860
-
Somatostatin and diabetes.Am J Med. 1981 Mar;70(3):619-26. doi: 10.1016/0002-9343(81)90584-2. Am J Med. 1981. PMID: 6111219 Review.
-
Somatostatinoma syndrome. Biochemical, morphologic and clinical features.N Engl J Med. 1979 Aug 9;301(6):285-92. doi: 10.1056/NEJM197908093010601. N Engl J Med. 1979. PMID: 377080
-
Paracrine control of glucagon release by somatostatin (Review).Int J Mol Med. 2014 Mar;33(3):491-8. doi: 10.3892/ijmm.2013.1605. Epub 2013 Dec 24. Int J Mol Med. 2014. PMID: 24366344 Review.
Cited by
-
The nature of diabetes.J R Soc Med. 1978 Mar;71(3):170-9. doi: 10.1177/014107687807100304. J R Soc Med. 1978. PMID: 344881 Free PMC article. No abstract available.
-
Neurofibromatosis, phaeochromocytoma, and somatostatinoma.Br Med J (Clin Res Ed). 1982 Dec 4;285(6355):1618-9. doi: 10.1136/bmj.285.6355.1618. Br Med J (Clin Res Ed). 1982. PMID: 6128052 Free PMC article. No abstract available.
-
Calcitonin-producing pancreatic somatostatinoma: report of a case.Surg Today. 1998;28(12):1279-82. doi: 10.1007/BF02482815. Surg Today. 1998. PMID: 9872549 Review.
-
Well-differentiated pancreatic neuroendocrine tumors: from genetics to therapy.Nat Rev Gastroenterol Hepatol. 2012 Feb 7;9(4):199-208. doi: 10.1038/nrgastro.2012.9. Nat Rev Gastroenterol Hepatol. 2012. PMID: 22310917 Free PMC article. Review.
-
Somatostatinoma--the most recently described pancreatic islet cell tumor.West J Med. 1985 Mar;142(3):393-7. West J Med. 1985. PMID: 2859702 Free PMC article. No abstract available.