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. 1977 Mar 26;1(8013):671-5.
doi: 10.1016/s0140-6736(77)92115-8.

Balkan (endemic) nephropathy and a toxin-producing strain of Penicillium verrucosum var cyclopium: An experimental model in rats

J M Barnes, P K Austwick, R L Carter, F V Flynn, G C Peristianis, W N Aldridge

Balkan (endemic) nephropathy and a toxin-producing strain of Penicillium verrucosum var cyclopium: An experimental model in rats

J M Barnes et al. Lancet. .

Abstract

Cultures of an isolate of Penicillium verrucosum var. cyclopium, obtained from stored maize in an area of Balkan (endemic) nephropathy--Vratza, Bulgaria--has consistently induced renal tubular lesions when force-fed to rats for 20 days. The lesions, confined to the lower reaches of the proximal convoluted tublues (pars recta and junctional zone), closely resemble the tubular changes in patients with Balkan nephropathy. Preliminary evidence suggests that this nephrotoxin-producing strain of P. verrucosum var. cyclopium may be implicated in the aetiology of Balkan nephropathy.

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References

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    1. Puchlev A., editor. Bulgarian Academy of Sciences; Sofia: 1965. (International Symposium on Endemic Nephropathy).
    1. Lancet. 1966;i:304.
    1. Wolstenholme G.E.W., Knight J., editors. 1967. (The Balkan Nephropathy). London.
    1. Puchlev A., editor. Bulgarian Academy of Sciences; Sofia: 1974. (Endemic Nephropathy).

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