Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Dec;42(6):680-3.
doi: 10.1136/ard.42.6.680.

1 Alpha 2 alpha 3 alpha collagen is arthritogenic

K Morgan, H B Evans, S A Firth, M N Smith, S Ayad, J B Weiss, P J Lennox Holt

1 Alpha 2 alpha 3 alpha collagen is arthritogenic

K Morgan et al. Ann Rheum Dis. 1983 Dec.

Abstract

Native 1 alpha 2 alpha 3 alpha collagen (500 micrograms per rat) was both immunogenic and arthritogenic in Alderley Park rats (46% developed arthritis) but only immunogenic in Sprague-Dawley rats. Conversely, native type II collagen (500 micrograms per rat) was immunogenic and arthritogenic in both strains (64% arthritic in Alderley Park strain, 57% arthritic in Sprague-Dawley strain). The inflammatory polyarthritis induced by 1 alpha 2 alpha 3 alpha collagen was similar to that produced by native type II collagen in clinical appearance, time of onset, and histology. Antibodies raised to native bovine type II collagen cross-reacted with native 1 alpha 2 alpha 3 alpha collagen and vice versa. Thus the minor collagen component of cartilage, the 1 alpha 2 alpha 3 alpha collagen, as well as the major collagen component, type II collagen, are immunogenic and arthritogenic in the rat, with strain differences.

PubMed Disclaimer

References

    1. Ann Rheum Dis. 1980 Jun;39(3):285-90 - PubMed
    1. FEBS Lett. 1981 Jan 26;123(2):195-9 - PubMed
    1. Arthritis Rheum. 1981 Jun;24(6):781-9 - PubMed
    1. FEBS Lett. 1982 Mar 22;139(2):300-4 - PubMed
    1. Anal Biochem. 1962 Oct;4:330-4 - PubMed

Publication types