Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1983 Dec;10(4):311-33.
doi: 10.1016/0165-4608(83)90090-0.

Nonrandom chromosomal changes in untreated retinoblastomas

W F Benedict, A Banerjee, C Mark, A L Murphree

Nonrandom chromosomal changes in untreated retinoblastomas

W F Benedict et al. Cancer Genet Cytogenet. 1983 Dec.

Abstract

The karyotypic patterns of 15 retinoblastomas were examined. Five tumors were found to have two distinct stem lines and, therefore, the chromosomal patterns of 20 tumor cell lines are reported. Three nonrandom chromosomal changes, namely, a loss of a chromosome #13, the presence of an i(6p), or a trisomy of 1q were observed. The potential importance of these chromosomal changes in tumor development is discussed, particularly the loss of a chromosome #13 or the gain of an i(6p). At least one of the three chromosomal changes was found in 75% of the tumor lines analyzed.

PubMed Disclaimer

Publication types

LinkOut - more resources