Formal genetics of isoniazid metabolism in man
- PMID: 6653034
- DOI: 10.2165/00003088-198308060-00005
Formal genetics of isoniazid metabolism in man
Abstract
Complex segregation analysis of the isoniazid inactivator phenotype has shown the existence of a recessive gene and a multifactorial background. The phenotype is also influenced by age, sex and weight. The relevance of these findings to the grouping of individuals into slow and rapid inactivators is stressed.
Similar articles
-
Effect of prednisolone and rifampin on isoniazid metabolism in slow and rapid inactivators of isoniazid.Antimicrob Agents Chemother. 1980 Nov;18(5):661-6. doi: 10.1128/AAC.18.5.661. Antimicrob Agents Chemother. 1980. PMID: 7447424 Free PMC article.
-
Acetylator phenotyping with sulphadimidine in patients receiving isoniazid.Int J Clin Pharmacol Res. 1984;4(2):141-4. Int J Clin Pharmacol Res. 1984. PMID: 6469440
-
High frequency of the rapid isoniazid acetylator phenotype in Lagos (Nigeria).Hum Hered. 1989;39(1):26-31. doi: 10.1159/000153827. Hum Hered. 1989. PMID: 2759621
-
Genetically determined variability in acetylation and oxidation. Therapeutic implications.Drugs. 1985 Apr;29(4):342-75. doi: 10.2165/00003495-198529040-00003. Drugs. 1985. PMID: 2859977 Review.
-
Clinical pharmacokinetics of isoniazid.Clin Pharmacokinet. 1979 Nov-Dec;4(6):401-22. doi: 10.2165/00003088-197904060-00001. Clin Pharmacokinet. 1979. PMID: 391461 Review.
Cited by
-
Ageing and acetylator phenotype.Eur J Clin Pharmacol. 1985;29(3):377. doi: 10.1007/BF00544098. Eur J Clin Pharmacol. 1985. PMID: 4076335 No abstract available.
-
The potential and limitations of personalised medicine in primary care.Br J Gen Pract. 2003 Dec;53(497):915-6. Br J Gen Pract. 2003. PMID: 14960213 Free PMC article. No abstract available.
-
The genetic control of phenformin 4-hydroxylation.J Med Genet. 1985 Oct;22(5):361-6. doi: 10.1136/jmg.22.5.361. J Med Genet. 1985. PMID: 4078865 Free PMC article.
-
Human acetylator genotype: relationship to colorectal cancer incidence and arylamine N-acetyltransferase expression in colon cytosol.Arch Toxicol. 1993;67(7):445-52. doi: 10.1007/BF01969914. Arch Toxicol. 1993. PMID: 7902079
-
N-acetylation polymorphism of dapsone in a Japanese population.Br J Clin Pharmacol. 1988 Apr;25(4):487-94. doi: 10.1111/j.1365-2125.1988.tb03333.x. Br J Clin Pharmacol. 1988. PMID: 3382590 Free PMC article.
References
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources