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. 1983 Nov-Dec;8(6):541-4.
doi: 10.2165/00003088-198308060-00005.

Formal genetics of isoniazid metabolism in man

L Iselius, D A Evans

Formal genetics of isoniazid metabolism in man

L Iselius et al. Clin Pharmacokinet. 1983 Nov-Dec.

Abstract

Complex segregation analysis of the isoniazid inactivator phenotype has shown the existence of a recessive gene and a multifactorial background. The phenotype is also influenced by age, sex and weight. The relevance of these findings to the grouping of individuals into slow and rapid inactivators is stressed.

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