Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1977 Apr 9;1(8015):767-71.
doi: 10.1016/s0140-6736(77)92955-5.

Phenylalanine metabolism and intellectual functioning among carriers of phenylketonuria and hyperphenylalaninaemia

R C Ford, J L Berman
Comparative Study

Phenylalanine metabolism and intellectual functioning among carriers of phenylketonuria and hyperphenylalaninaemia

R C Ford et al. Lancet. .

Abstract

All members of 63 families who had phenylketonuric or hyperphenylalaninaemic offspring received a phenylalanine tolerance test and an individual intelligence test. Parent carriers (heterozygotes, n=115) displayed a significant relationship (canonical correlation R=0.75, P is less than 0.05) between their ability to metabolise phenylalanine and their intellectual strengths and weaknesses. Mothers of hyperphenylalaniaemic children did not show this relationship. The number of carrier children (n=40) was too small for multivariate or sex analysis, but significant bivariate correlations were found for this group.

PubMed Disclaimer

Publication types