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. 1983 Nov;8(11):1471-80.
doi: 10.1007/BF00965002.

Utilization of tyrosine and tryptophan for protein synthesis by undernourished developing rat brain

S Kalyanasundaram, P S Ramanamurthy

Utilization of tyrosine and tryptophan for protein synthesis by undernourished developing rat brain

S Kalyanasundaram et al. Neurochem Res. 1983 Nov.

Abstract

Incorporation of tracer doses of radiolabeled tryptophan and tyrosine into brain proteins was investigated in rats malnourished during gestation and lactation. Age and time dependent increases in the radioactivity was observed in the whole homogenate and in the TCA insoluble fraction. Protein malnourished rats showed increased incorporation of tryptophan and tyrosine. However the diet restricted (Pair-fed) animals showed increased incorporation of tyrosine only. The increased incorporation may probably be due to changes in the pool size of the amino acids and effective recycling of the amino acids. The enhanced utilization in protein synthesis may also probably offer a mechanism for conservation of these amino acids.

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