Comparative Study
doi: 10.1016/0304-3940(83)90428-7.
Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam
- PMID: 6657152
- DOI: 10.1016/0304-3940(83)90428-7
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Comparative Study
Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam
Neurosci Lett.
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Abstract
The development of tolerance to the protective effects of diazepam (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) were studied in 3 strains of mice. Significant tolerance developed to protection against myoclonic jerks induced by PTZ (90-100 mg/kg) by day 5 in Tuck No. 1 and by day 10 in C3H/HE and CD-1 mice. Tolerance developed to protection against tonic-clonic convulsions by day 10 in Tuck No. 1 mice and by day 30 in the other strains. Diazepam remained protective against tonic-clonic convulsions (but not against myoclonus) induced by threshold doses of PTZ for 30 days in all 3 strains.
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