[Pseudouridine excretion with urine and RNA metabolism in experimental myocardial infarction and its correction]

Abstract

It is established that the acute period of the experimental myocardial infarction is characterized by an intensified excretion of pseudouridine with urine. Simultaneously in the "non-ischemic" area of the left cardiac ventricle as well as in the liver there occurs an activation of the transport and ribosomal RNA synthesis. RNA preparations from the liver show that the nucleotide composition of tRNA changes with the myocardium infarction. When a complex consisting of l-forms of aspartate, glutamate, leucine, histidine, 4-methyl uracil, tracilole, tris (rN 7.4) was injected during the acute period, the excretion of pseudouridine decreases, synthesis of different RNA types activates and the pseudouridine content in tRNA of the liver normalizes.